Synthesis, Crystal Structure and Antitumor Study of a Zinc Complex of the 2-Benzoylpyridine Thiosemicarbazone Ligand
نویسندگان
چکیده
A zinc complex of the 2-benzoylpyridine thiosemicarbazone (Hbpt) ligand, Zn(bpt)2 ·DMF, has been synthesized and characterized by elemental analysis, IR spectra and single crystal X-ray diffraction. The molecular structure has a Zn2+ cation bonded to two perpendicular bpt ligands in a distorted octahedral geometry through two sulfur and four nitrogen atoms. The crystal contains a disordered DMF solvate molecule. Adjacent molecules are interconnected by means of hydrogen bonding generating a 1-D chain structure. The cytotoxic activity measurement indicates that the complex exhibits higher antitumor activity against lung cancer A549 cell lines than the free ligand.
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